PRINCIPLES OF ORGANIC SYNTHESIS By R.O.C. Norman

 

This is the third Edition of this book. Organic synthesis has gone through several developmental stages since the publication of the second edition of this book, therefore every chapter has been updated in the third edition to keep pace with the developments in the field. Some of the important addtions/updations in this edition are; the stereochemical control of reactions,  a new chapter on the use of  organotransition-metal reagents, the exploitation of lithium diisopropylamide (LDA) as a base in the formation of new C-C bonds; free-radical reactions for the synthesis of C-C bonds; uses of organosilicon compounds, and subtle new protective and condensing reagents in polypeptide synthesis.

The text is extensively cross-referenced and there is a detailed index.

The book comprises of 22 chapters, divided into two parts.

Part I is composed of five chapters (Chapter 1-5)

Part II is composed of seventeen chapters (Chapter 6-22)

TABLE OF CONTENTS

PART I

Introduction to Part I

1.    Chemical thermodynamics

2.    Molecular structure

3.    Chemical Kinetics

4.    Mechanism

5.    Stereochemistry

PART II

Introduction to Part II

6.      Formation of carbon-carbon bonds: organometallic reagents

7.      Formation of aliphatic carbon-carbon bonds: base-catalyzed            reactions 

8.     Formation of aliphatic carbon-carbon bonds: acid-catalyzed           reactions

9.     Pericyclic reactions

10.    Foramation of aliphatic carbon-nitrogen bonds

11.    Electrophilic aromatic substitution

12.    Nucleophilic aromatic substitution

13.    Aromatic diazonium salts

14.    Molecular rearrangements

15.    Reagents containing phosphorus, sulfur, silicon or boron

16.    Photochemical reactions

17.    Free-radical reactions

18.    Organotransition metal reagents

19.    Oxidation

20.    Reduction

21.    The synthesis of five- and six-membered heterocyclic compounds

22.    The syntheses of some naturally occurring compounds

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